Glutathione (600mg)

Endogenous tripeptide antioxidant (γ-glutamyl-cysteinyl-glycine). Built from glutamate, cysteine and glycine, glutathione is the cell's most plentiful internal antioxidant, present at millimolar levels in every cell. It mops up reactive oxygen species, regenerates vitamins C and E, and handles phase II detoxification in the liver. In its research-grade form it serves as a reference antioxidant and features in oxidative-stress assays.

Redox biology: gSH:GSSG ratio used as a marker of oxidative stress. Detoxification: phase II conjugation inside hepatocytes. Melanogenesis: tyrosinase inhibition within pigment-cell assays. Mitochondrial protection: buffering ROS in cells under stress. Oral and intravenous glutathione have been trialled in oxidative-stress conditions, skin pigmentation and liver disease, and the outcomes have been mixed, in part because the oral form absorbs poorly. Laboratory studies lean on it as a positive control for antioxidant capacity and within melanogenesis assays.

In oral trials blood glutathione rose modestly while functional endpoints were mixed; intravenous studies in skin pigmentation and liver disease recorded short-term changes. Within the laboratory it functions as a reference antioxidant.

Trials generally find both oral and intravenous glutathione well tolerated, though intravenous use at unregulated clinics has drawn reports of adverse reactions. This research powder is meant for laboratory work.

In the published Glutathione research, the amounts used were 1,500 mg/m², intravenous infusion over 15 min, Before each oxaliplatin dose (bimonthly regimen) in human rct, colorectal cancer on oxaliplatin (Cascinu S et al. (2002)); 2,500 mg in 25 mL, intravenous infusion over 10 min, Before the procedure, then at 24, 48 and 72 hours in human pilot rct, stemi before angioplasty (Tanzilli G et al. (2019)); 250 or 1,000 mg, oral, Daily in human rct, healthy adults (Richie JP et al. (2015)). These are the figures each study reports for its own model, listed in full in the dosage table on this page with links to PubMed. Peptide Aus supplies Glutathione for in-vitro research and does not give dosing guidance for people.

Intravenous glutathione comes from clinics and the oral form from supplement shops, both of which sit outside research supply. Peptide Aus provides research-grade glutathione powder in a 600mg vial for laboratory use.

NAD+ serves as a redox coenzyme and a sirtuin substrate, whereas glutathione is the cell's principal thiol antioxidant. Both arrive in large vials ready for reconstitution.

NAC is a precursor to glutathione that absorbs better by mouth; glutathione is the completed tripeptide itself.

Unlike signalling peptides, glutathione is worked with at much higher concentrations, which is why the vial is this large. Expect to reconstitute it in a bigger volume than a typical peptide vial, roughly 6 mL.

Add about 6 mL of bacteriostatic water slowly down the inside of the vial and swirl gently; do not shake. 600mg in 6 mL gives 100 mg/mL. Refrigerate at 2–8 °C after reconstitution and use within 8–12 weeks. The calculator has this vial preset.

Lyophilised: −20 °C, sealed, away from light and moisture. Reconstituted: 2–8 °C, used within 8–12 weeks, never frozen.

The Therapeutic Goods Administration (TGA) has not registered Glutathione as a medicine in Australia, and it carries no approval for use in humans or animals. What Peptide Aus sells is a research reagent intended for in-vitro laboratory work and nothing more. In Australia, supplying any substance for human use falls under the Therapeutic Goods Act and the Poisons Standard, and it is the purchaser who must ensure the material is used within the law. Anyone seeking treatment should consult a doctor.

Directly from Peptide Aus, from Australian stock: Glutathione (600mg) is $79.99 AUD including GST. Paid orders before 2pm AEST/AEDT dispatch the same business day, tracked.