KPV (10mg)

C-terminal tripeptide of alpha-MSH (Lys-Pro-Val). KPV consists of the final three amino acids of alpha-melanocyte-stimulating hormone. It retains the parent hormone's anti-inflammatory action while shedding the pigmentation effect, which makes it a clean probe for studying melanocortin-driven control of inflammation, the gut especially.

Intestinal inflammation: dSS and TNBS colitis models. NF-κB signalling: suppression of cytokines in epithelial cells. Skin inflammation: wound and dermatitis models. Antimicrobial activity: fungal and bacterial assays. Reduced inflammation scores with both oral and systemic KPV were reported in mouse colitis studies (Dalmasso et al., Gastroenterology 2008). Skin models have looked at wound inflammation and at antimicrobial activity against Staphylococcus aureus and Candida.

Mouse colitis studies reported lower inflammation scores and cytokine levels with KPV, the oral route included; skin models reported less inflammatory infiltrate along with antimicrobial activity in culture.

No human trials have appeared in print. Rodent work reported no toxicity at the doses used, and KPV lacks the pigmentation effect of alpha-MSH, which was the point of its design.

In the published KPV research, the amounts used were Nanomolar concentrations in cell culture, human intestinal epithelial cells and t cells (Dalmasso G et al. (2008)); 10⁻¹⁵ to 10⁻⁷ M in cell culture, human keratinocytes (Elliott RJ et al. (2004)). These are the figures each study reports for its own model, listed in full in the dosage table on this page with links to PubMed. Peptide Aus supplies KPV for in-vitro research and does not give dosing guidance for people.

The colitis literature directly supports oral KPV, where it enters intestinal cells through the PepT1 transporter. For now Peptide Aus stocks the 10mg lyophilised vial, with a capsule format being considered.

BPC-157 is studied for gut protection via repair signalling, whereas KPV targets gut inflammation by suppressing NF-κB. KLOW brings the two together.

KPV is the final three residues of alpha-MSH, holding on to the anti-inflammatory action while dropping the melanocortin receptor effects.

Add about 2 mL of bacteriostatic water slowly down the inside of the vial and swirl gently; do not shake. 10mg in 2 mL gives 5 mg/mL. Refrigerate at 2–8 °C after reconstitution and use within 8–12 weeks. The calculator has this vial preset.

Lyophilised: −20 °C, sealed, away from light and moisture. Reconstituted: 2–8 °C, used within 8–12 weeks, never frozen.

The Therapeutic Goods Administration (TGA) has not registered KPV as a medicine in Australia, and it is not approved for human or veterinary use. Peptide Aus supplies it only as a research reagent for in-vitro laboratory work. In Australia the supply of any substance for human use falls under the Poisons Standard and the Therapeutic Goods Act, and the buyer carries responsibility for lawful use. Anyone seeking a treatment should talk to a doctor.

Directly from Peptide Aus, from Australian stock: KPV (10mg) is $89.99 AUD including GST. Paid orders before 2pm AEST/AEDT dispatch the same business day, tracked.