Selank (10mg)

Synthetic tuftsin analogue heptapeptide. Selank is the naturally occurring immunomodulatory tetrapeptide tuftsin lengthened with the same Pro-Gly-Pro tail found in Semax. The compound came from the same Moscow team and draws research interest for anxiolytic activity that avoids the sedation and dependence linked to benzodiazepines.

Anxiolytic research: open-field and elevated-plus-maze paradigms. GABAergic modulation: expression of receptor subunits. Enkephalin metabolism: inhibition of peptidases. Immune signalling: cytokine expression arising from tuftsin activity. In Russian clinical trials for generalised anxiety disorder, selank produced effects on a par with medazepam yet without the sedation. Rodent experiments report less anxiety-like behaviour together with shifts in GABAergic gene expression.

Russian anxiety trials described anxiolytic effects matching a benzodiazepine while avoiding sedation; rodent work reported less anxious behaviour and altered GABA-A subunit expression.

No dependence, sedation or withdrawal surfaced in the Russian trials, and controlled safety data from Western sources are not available.

In the published Selank research, the amounts used were 0.3 mg/kg intraperitoneal, Single injection in rat, morphine withdrawal model (Konstantinopolsky MA et al. (2022)); 0.3 mg/kg intraperitoneal, Daily in rat, chronic ethanol model (Kolik LG et al. (2019)); 100, 300 or 1000 μg/kg intraperitoneal, 15 min before each stress session in rat (male wistar), chronic foot-shock stress (Fomenko EV et al. (2019)). These are the figures each study reports for its own model, listed in full in the dosage table on this page with links to PubMed. Peptide Aus supplies Selank for in-vitro research and does not give dosing guidance for people.

In Russia selank is taken as a nasal preparation, but the sprays on sale online are unverified; Peptide Aus provides the 10mg vial for laboratory research.

Where selank is aimed at anxiety, semax is aimed at cognition.

An altered form promoted for longer action, though the supporting evidence concerns the original sequence.

Add about 2 mL of bacteriostatic water slowly down the inside of the vial and swirl gently; do not shake. 10mg in 2 mL gives 5 mg/mL. Refrigerate at 2–8 °C after reconstitution and use within 8–12 weeks. The calculator has this vial preset.

Lyophilised: −20 °C, sealed, away from light and moisture. Reconstituted: 2–8 °C, used within 8–12 weeks, never frozen.

In Australia, Selank holds no Therapeutic Goods Administration (TGA) registration as a medicine and carries no approval for use in humans or animals. The material is offered by Peptide Aus strictly as a research reagent intended for in-vitro laboratory work. The Poisons Standard and the Therapeutic Goods Act set the rules for supplying any substance for human use in this country, and lawful use of the material rests with the buyer. Anyone seeking treatment should consult a doctor.

Directly from Peptide Aus, from Australian stock: Selank (10mg) is $94.99 AUD including GST. Paid orders before 2pm AEST/AEDT dispatch the same business day, tracked.