Semax (10mg)

Synthetic ACTH (4-10) analogue heptapeptide. Built from seven amino acids, Semax takes the ACTH (4-10) fragment and appends a Pro-Gly-Pro tail that lends it stability. The compound originated at Moscow's Institute of Molecular Genetics and has seen clinical use in Russia as a nasal preparation for stroke and cognitive conditions; outside that country it functions purely as a research material.

BDNF signalling: neurotrophin expression in the hippocampus. Neuroprotection: models of ischaemia and oxidative stress. Attention and memory: learning tasks in rodents. Monoamine modulation: turnover of serotonin and dopamine. Clinical work in Russia describes better results in ischaemic stroke and in tasks measuring attention. In rodents, studies from Dolotov et al. demonstrate upregulated BDNF and improved maze learning. What remains missing is independent trial data from Western groups.

Clinical studies in Russia described better neurological recovery after stroke and higher attention scores; in rodents, researchers reported BDNF upregulation along with improved maze performance.

The Russian literature describes it as well tolerated and free of hormonal activity. No controlled safety data from Western sources are available.

In the published Semax research, the amounts used were 12 mg/day (moderate) or 18 mg/day (severe), reported as most effective, Daily in human, acute ischaemic stroke (Gusev EI et al. (1997)); Intranasal 1% solution, 2–4 drops, Three times a day in human, refractory peptic ulcer (Ivanikov IO et al. (2002)). These are the figures each study reports for its own model, listed in full in the dosage table on this page with links to PubMed. Peptide Aus supplies Semax for in-vitro research and does not give dosing guidance for people.

Russia registers semax as a nasal preparation, but the sprays offered online come with no confirmed content; what Peptide Aus stocks is the 10mg lyophilised vial for laboratory research.

Semax is examined for cognition and neuroprotection while selank is examined for anxiety; the two share both a Pro-Gly-Pro tail and a Moscow origin.

The N-acetyl and amidate variants are altered forms said to persist longer, yet the published research sits with the original sequence.

Add about 2 mL of bacteriostatic water slowly down the inside of the vial and swirl gently; do not shake. 10mg in 2 mL gives 5 mg/mL. Refrigerate at 2–8 °C after reconstitution and use within 8–12 weeks. The calculator has this vial preset.

Lyophilised: −20 °C, sealed, away from light and moisture. Reconstituted: 2–8 °C, used within 8–12 weeks, never frozen.

In Australia, Semax holds no Therapeutic Goods Administration (TGA) registration as a medicine and carries no approval for use in humans or animals. The material is offered by Peptide Aus strictly as a research reagent intended for in-vitro laboratory work. The Poisons Standard and the Therapeutic Goods Act set the rules for supplying any substance for human use in this country, and lawful use of the material rests with the buyer. Anyone seeking treatment should consult a doctor.

Directly from Peptide Aus, from Australian stock: Semax (10mg) is $69.99 AUD including GST. Paid orders before 2pm AEST/AEDT dispatch the same business day, tracked.